ASH Clinical News Advances in Hematology Research & Patient Care: Hi | Page 4

DISCOVERING HOW FAR THERAPY CAN GO
IMPORTANT SAFETY INFORMATION
WARNINGS AND PRECAUTIONS
Hemorrhage - Fatal bleeding events have occurred in patients
treated with IMBRUVICA®. Grade 3 or higher bleeding events
(subdural hematoma, gastrointestinal bleeding, hematuria, and
post-procedural hemorrhage) have occurred in up to 6% of
patients. Bleeding events of any grade, including bruising and
petechiae, occurred in approximately half of patients treated
with IMBRUVICA®.
The mechanism for the bleeding events is not well understood.
IMBRU Y%