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FEATURE PhRMA, only about two-thirds (63%) of a branded drug’s list price is retained by the companies, with one-third going back to payers, the government, or other stakehold- ers. 13 Of that revenue, about 20% is then re-invested in research and development for new treatments. “The biotech market is considered a high-risk, high- reward area of investment,” Dr. Fonseca noted. Economic trade-offs exist between cancer drug pricing and innova- tion, he continued, with several studies having shown that a reduction in drug profitability stifles innovation and investment. 14 So, while lower prices could increase access to drugs, they may reduce access to innovative therapies in the future. Dr. Rajkumar, however, takes the opposite stance: “The fact that pharmaceutical companies can price a drug high regardless of whether or not it is innovative or just a modification, like an analog rather than a new class of drugs, is the enemy of innovation.” What a Life Is Worth Commenting on the new treatment options for myeloma, Dr. Usmani said that, “All of these developments are won- derful for patients, but the important question is, ‘Can we continue to pay for all these drugs?’ What does the introduction of so many myeloma therapies mean for our patients who are dealing with copays and out-of-pocket expenses for their cancer care?” Dr. Fonseca, for one, believes that the extended sur- vival seen with newer treatment approaches is worth the high costs. “We would not have all of this progress absent these expensive drugs,” he said. However, Dr. Carlson and members of the Institute of Clinical and Economic Review (ICER) disagree. The organization recently looked at the cost-effectiveness of drugs used to treat relapsed or refractory MM in the U.S., evaluating carfilzomib, elotuzumab, ixazomib, daratumumab, and panobinostat in combination with lenalidomide, or bortezomib plus dexamethasone as second- or thirdline therapy. 15 The introduction of these regimens appeared to provide clinical benefit by length- ening progression-free and overall survival and improv- ing quality of life. However, using a cost-effectiveness threshold of $150,000 per quality-adjusted life-year, ICER found that “only the addition of daratumumab or panobinostat may be considered cost-effective options.” The authors concluded that “achieving levels of value more closely aligned with patient benefit would require substan- tial discounts from the remaining agents evaluated.” “Critics will say that quality-adjusted life-years have some limitations, and that is true,” Dr. Carlson told ASH Clinical News, “but it is the best measure we have and has been widely adopted.” A similar study comparing carfilzomib, daratumumab, and pomalidomide plus low-dose dexamethasone in re- lapsed or refractory MM suggested that the pomalidomide- dexamethasone combination may be the most cost-effective option. 16 Assuming equal efficacy of the regimens, the doublet regimen resulted in a cost-savings of about $12,000 over the two other agents. Because it is not practical to have direct comparisons for all regimens, creative cross-trial comparisons may be useful. Despite the results reported in these studies, the nature of MM is that most patients likely will require sequential treatment with a majority of the available agents to achieve the best possible outcomes. Dr. Carlson encouraged clinicians to consider cost- effectiveness during treatment selection, no matter what patients are willing to pay. “At some point, people need to understand that when we pay for medical treatments, we have to give up paying ASHClinicalNews.org for other things… like education or infrastructure.” Dr. Fonseca again noted the trade-offs that come with demanding lower prices for novel therapeutics. For example, more drugs are available in the U.S. and become available more quickly than in other countries. “In the U.S., we are blessed that we have access to drugs for our patients with myeloma, but at the same time, we are a little frivolous with the spending part of it. There needs to be some reconciliation.” —SAAD USMANI, MD “The reality is that access to drugs in countries like the U.K. occurs at a much later time than it does in the U.S.,” Dr. Fonseca said. “In turn, patients have inferior outcomes. It is a trade-off of spending less and having less access or spending more with earlier access.” “In the U.S., we are blessed that we have access to drugs for our patients with myeloma, but at the same time, we are a little frivolous with the spending part of it,” Dr. Usmani noted. “There needs to be some reconciliation.” Solutions in Sight? A variety of solutions have been proposed to begin to rein in drug prices, at all levels of the drug-pricing system, but finding real solutions will require the participation of all stakeholders, Dr. Usmani added. “This issue has not been looked at systemically,” he said. “Physicians have been talking about it from their perspective, and patients have been talking about it from theirs. We need to have broader discussions about myeloma treatment costs that culminate in solutions.” One concept is value-based reimbursement and pric- ing, which would allow the Centers for Medicare and Medicaid Services (CMS) or other agencies to negotiate the sale price of a drug based on the incremental value provided by that drug. “Developed countries except the U.S. have a system where approval of a drug is only the first step,” Dr. Rajkumar said. “The second step is a negotiation of the price based on the value that new drug will bring.” Dr. Rajkumar also supported an increase to com- petition by allowing for easier entry for generics and biosimilars into the market and patent reform. Legislative efforts have stalled in the past, but they may have received renewed interest recently, thanks to the introduction of biosimilars. Earlier this year, Sen. Patrick Leahy (D-VT), re- introduced the Creating and Restoring Equal Access To Equivalent Samples (CREATES) Act, which – among other policies – would allow a biosimilar or generic developer to bring a civil action against an innovator drug company if the latter refuses to make available enough samples of a product for testing. 17 The CREATES Act was first intro- duced in 2016 and has enjoyed broad bipartisan support but has not been voted on since its introduction. “The more generics that come into the market, the more likely prices are to fall,” he said. “We’ve seen it hap- pen with imatinib and many other prescription drugs.” These suggested solutions aren’t new, and few – if any – have gained significant traction, but hematologists and oncologists should still be paying attention. “Several parties are involved in the pricing of and pay- ment for myeloma treatment,” Dr. Usmani said. “It’s not just the pharmaceutical industry or the insurance industry or the health-care organization or the patient advocacy groups or the treating physician – it’s all of us together. We need to find a way to bring all of these stakeholders together to actually start finding a solution.” “We need to step up and we need allies. Big organi- zations need to step up, too, and forget about what big pharma brings them,” Dr. Rajkumar added. “We need to call people to task. If we don’t, who will?” ● —By Leah Lawrence REFERENCES 1. Pear R.. Drug makers try to justify prescription prices to senators at hearing. The New York Times. Accessed May 8, 2019, from https://www.nytimes.com/2019/02/26/us/politics/ prescription-drug-prices.html. 2. Cunningham PW. The Health 202: Lawmakers are trying to prove they’re serious about lowering drug costs. The Washington Post. Accessed May 8, 2019, from https://www. washingtonpost.com/news/powerpost/paloma/the-health-202/2019/04/11/the-health- 202-lawmakers-are-trying-to-prove-they-re-serious-about-lowering-drug-costs/5cadff831 ad2e567949ec11d/?noredirect=on&utm_term=.aebf172a0906. 3. Rajkumar SV, Gertz MA, Kyle RA, et al. 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The importance of economic trade-offs in cancer drug pricing. Mayo Clin Proc. 2018;93:976-9. 15. Carlson JJ, Guzauskas GF, Chapman RH, et al. Cost-effectiveness of drugs to treat relapsed/ refractory multiple myeloma in the United States. J Manag Care Spec Pharm. 2018;24:29-38. 16. Pelligra CG, Parikh K, Guo S, et al. Cost-effectiveness of pomalidomide, carfilzomib, and daratumumab for the treatment of patients with heavily pretreated relapsed-refractory multiple myeloma in the United States. Clin Ther. 2017;39:1986-2005. 17. Congress.gov. S.974 - Creating and Restoring Equal Access to Equivalent Samples Act of 2018. Accessed May 7, 2019, from https://www.congress.gov/bill/115th-congress/senate- bill/974. ASH Clinical News 47