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GAZYVA Is the First and Only Approved Therapy That Demonstrated Superior PFS * vs rituximab in Previously Untreated FL 1 FIRST AND ONLY With chemotherapy † for stage II bulky, III, and IV patients GAZYVA and rituximab were each combined with bendamustine, CHOP, or CVP, and followed by GAZYVA or rituximab monotherapy, respectively, in patients who responded. * HR=0.72, 95% CI, 0.56-0.93; P=0.0118; PFS events, 108 (18%) in the GAZYVA arm vs 141 (23.5%) in the rituximab arm; 38-month median observation time. † Important Safety Information (cont’d) Infusion Reactions (cont’d) Infections • For patients with any Grade 4 infusion reactions, including but not limited to anaphylaxis, acute life- threatening respiratory symptoms, or other life- threatening infusion reaction: Stop the GAZYVA infusion. Permanently discontinue GAZYVA therapy • For patients with Grade 1, 2, or 3 infusion reactions: Interrupt GAZYVA for Grade 3 reactions until resolution of symptoms. Interrupt or reduce the rate of the infusion for Grade 1 or 2 reactions and manage symptoms • For patients with preexisting cardiac or pulmonary conditions, monitor more frequently throughout the infusion and the post-infusion period since they may be at greater risk of experiencing more severe reactions. Hypotension may occur as part of the GAZYVA infusion reaction. Consider withholding antihypertensive treatments for 12 hours prior to and during each GAZYVA infusion, and for the fi rst hour after administration until blood pressure is stable. For patients at increased risk of hypertensive crisis, consider the benefi ts versus the risks of withholding their antihypertensive medication Hypersensitivity Reactions Including Serum Sickness • Hypersensitivity reactions have been reported in patients treated with GAZYVA. Signs of immediate- onset hypersensitivity included dyspnea, bronchospasm, hypotension, urticaria and tachycardia. Late-onset hypersensitivity diagnosed as serum sickness has also been reported with symptoms that include chest pain, diff use arthralgia and fever. Hypersensitivity reactions may be diffi cult to clinically distinguish from infusion related reactions. However, hypersensitivity very rarely occurs with the fi rst infusion and, when observed, often occur after previous exposure. If a hypersensitivity reaction is suspected during or after an infusion, the infusion must be stopped and treatment permanently discontinued. Patients with known hypersensitivity reactions to GAZYVA, including serum sickness, must not be retreated Tumor Lysis Syndrome (TLS) • Tumor lysis syndrome, including fatal cases, has been reported in patients receiving GAZYVA. Patients with high tumor burden, high circulating lymphocyte count (>25 x 10 9 /L) or renal impairment are at greater risk for TLS and should receive appropriate tumor lysis prophylaxis with antihyperuricemics (eg, allopurinol or rasburicase) and hydration prior to the infusion of GAZYVA. During the initial days of GAZYVA treatment, monitor the laboratory parameters of patients considered at risk for TLS. For treatment of TLS, correct electrolyte abnormalities, monitor renal function and fl uid balance, and administer supportive care, including dialysis as indicated • Fatal and serious bacterial, fungal, and new or reactivated viral infections can occur during and following GAZYVA therapy. When GAZYVA is administered with chemotherapy followed by GAZYVA monotherapy, Grade 3 to 5 infections have been reported in up to 8% of patients during combination therapy, up to 13% of patients during monotherapy, and up to 8% of patients after treatment. Do not administer GAZYVA to patients with an active infection. Patients with a history of recurring or chronic infections may be at increased risk of infection • In GALLIUM, more Grade 3 to 5 infections were reported in the recipients of GAZYVA and bendamustine (117/410 patients, 29%), as compared to GAZYVA plus CHOP or CVP (43/281 patients, 15%). More fatal infections were reported in patients treated with GAZYVA and bendamustine (3%), as compared to GAZYVA plus CHOP or CVP (<1%), including during the monotherapy phase and after completion of treatment Neutropenia • Severe and life-threatening neutropenia, including febrile neutropenia, has been reported during treatment with GAZYVA. Monitor patients with Grade 3 to 4 neutropenia frequently with regular laboratory tests until resolution. Anticipate, evaluate, and treat any symptoms or signs of developing infection. Consider administration of granulocyte colony-stimulating factors (GCSF) in patients with Grade 3 or 4 neutropenia • Neutropenia can also be of late onset (occurring more than 28 days after completion of treatment) and/or prolonged (lasting longer than 28 days) • Consider dose delays in the case of Grade 3 or 4 neutropenia. Patients with severe and long lasting (>1 week) neutropenia are strongly recommended to receive antimicrobial prophylaxis until resolution of neutropenia to Grade 1 or 2. Consider antiviral and antifungal prophylaxis Thrombocytopenia • Severe and life threatening thrombocytopenia has been reported during treatment with GAZYVA in combination with chemotherapy. Fatal hemorrhagic events have been reported in patients with NHL treated with GAZYVA in combination with chemotherapy, including during Cycle 1. Monitor all patients frequently for thrombocytopenia and hemorrhagic events, especially during the fi rst cycle. In patients with Grade 3 or 4 thrombocytopenia, monitor platelet counts more frequently until resolution and consider subsequent dose delays of GAZYVA and chemotherapy or dose reductions of chemotherapy. Transfusion of blood products (i.e., platelet transfusion) may be necessary. Consider withholding concomitant medications which may increase bleeding risk (platelet inhibitors or anticoagulants), especially during the fi rst cycle