Erythroid Maturation
Needs to Stay on Track
Impaired maturation contributes to ineffective erythropoiesis,
which can lead to chronic anemia 1,2
• Ineffective erythropoiesis may be characterized by increased proliferation of erythroblasts, increased erythroid cell
death, and impaired erythroid maturation, which may result in chronic anemia 3,4
• Chronic anemia can have long-term consequences for patients with various blood disorders, such as myelodysplastic
syndromes (MDS), β-thalassemia, myelofibrosis, and Diamond-Blackfan anemia 5-8
Research is expanding what we know.
References: 1. Liang R, Ghaffari S. Advances in understanding the mechanisms of erythropoiesis in homeostasis and disease. Br J Haematol. 2016;174(5):661-673. 2. Santini V.
Anemia as the main manifestation of myelodysplastic syndromes. Semin Hematol. 2015;52(4):348-356. 3. Oikonomidou PR, Rivella S. What can we learn from ineffective
erythropoiesis in thalassemia? Blood Rev. 2018;32(2):130-143. 4. Paulson RF. Targeting a new regulator of erythropoiesis to alleviate anemia. Nat Med. 2014;20(4):334-335.
5. Jädersten M, Malcovati L, Dybedal I, et al. Erythropoietin and granulocyte-colony stimulating factor treatment associated with improved survival in myelodysplastic
syndrome. J Clin Oncol. 2008;26(21):3607-3613. 6. Naymagon L, Mascarenhas J. Myelofibrosis-related anemia: current and emerging therapeutic strategies. HemaSphere.
2017;1(1):e1. 7. Origa R. β-Thalassemia. Genet Med. 2017;19(6):609-619. 8. Vlachos A, Ball S, Dahl N, et al; Participants of Sixth Annual Daniella Maria Arturi International
Consensus Conference. Diagnosing and treating Diamond Blackfan anaemia: results of an international clinical consensus conference. Br J Haematol. 2008;142(6):859-876.