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* Bone complications, also known as skeletal-related events (SREs), are defi ned as radiation to bone, pathologic
fracture, surgery to bone, and spinal cord compression. 1
In a randomized, double-blind, phase 3 study (N=1,718) assessing time to fi rst on-study bone complication in patients with
bone lesions from multiple myeloma, XGEVA ® was noninferior to zoledronic acid in delaying time to fi rst on-study bone
complication (median 22.8 months vs 24 months, respect