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VOLUME 04 | NUMBER 02 JANUARY 2018 ANNUAL MEETING EDITION Around the Network AMERICAN SOCIETY OF HEMATOLOGY (ASH) HEADQUARTERS 2021 L Street NW, Suite 900 Washington, DC 20036 www.hematology.org Tel: [phone] IN THIS ISSUE on location How Should We Use Newly Approved Drugs in Practice? EDITOR-IN-CHIEF Mikkael Sekeres, MD, MS Vice-Chair for Clinical Research Director, Leukemia Program Cleveland Clinic, Taussig Cancer Institute Cleveland, OH As the number of treatment options for hematologic malignancies expands, so do questions incorporating these new agents into clinical practice. Experts discuss the clinical applications of five newly approved treatments for acute lymphocytic leukemia and non-Hodgkin lymphoma. ASSOCIATE EDITORS 26 Beth Faiman, CNP, PhD Cleveland Clinic Cleveland, OH Alice Ma, MD University of North Carolina School of Medicine Chapel Hill, NC David Steensma, MD Dana-Farber Cancer Institute Boston, MA Keith Stewart, MBChB, MBA Mayo Clinic Scottsdale, AZ New Drugs, New Insights This month, we take a deep dive into the 2017 ASH Annual Meeting, including a look at the first anti-sickling agent for sickle cell disease and research questioning the role of bleomycin in frontline Hodgkin lymphoma treatment. 26 clinical news 18 Duvelisib Appears Safe and Effective in Phase I Study 24 Vadastuximab Talirine a Potential Treatment for AML 25 Previous Malignancy Raises Myeloma Patients’ Risk of Subsequent Malignancy PUBLISHER American Medical Communications (AMC) EDITORIAL MANAGING EDITORS Kristin Hubing, ASH Ariel Jones-DeMaio, AMC ASSOCIATE MANAGING EDITOR Kerri Fitzgerald, AMC EDITORIAL ASSOCIATE Laurie Adamson, ASH ART DIRECTOR Ari Mihos ASSISTANT ART DIRECTORS Charlene DePrizio John Salesi DIGITAL PROJECTS MANAGER Chris Gedikli ADVERTISING ACCOUNT MANAGERS Nick Luciano [email protected] ASHCLINICALNEWS.ORG @ASHCLINICALNEWS The 59th ASH Annual Meeting & Exposition featured a jam-packed scientific and education program. In this special issue, we’re bringing you more reports from the meeting. Check out page 26 for an in-depth look into the practice-changing research presented at the meeting. Also, visit ashclinicalnews.org/ on-location for our complete coverage, including exclusive content available only online. Hear from the presenters and experts we spoke with at the meeting by visiting ashclinicalnews.org/multimedia. Search #ASH17 to catch up on what you missed at the annual meeting and make sure to follow us at @ASHClinicalNews. And don’t fo rget to sign up to receive our eNewsletters to have the latest updates from ASH Clinical News delivered to your inbox: ashclinicalnews.org/ enewsletter-sign-up. Gene Conselyea [email protected] Sima Sherman [email protected] Recruitment advertising orders can be sent to: DIRECTOR, RECRUITMENT CLASSIFIEDS Lauren Morgan [email protected] Visit us at ashclinicalnews.org Follow us on Twitter @ASHClinicalNews ©2018 by the American Society of Hematology. All materials contained in this newsletter are protected by copyright laws and may not be used, reproduced, or oth- erwise exploited in any manner without the express prior written permission of ASH Clinical News. Any third-party materials communicated to ASH Clinical News become its copyrighted property and may be used, reproduced, or otherwise exploited by ASH Clinical News. ASHClinicalNews.org Subscription inquiries should be sent to: [email protected] All correspondence for the American Society of Hematology should be sent to: American Society of Hematology, 2021 L Street NW, Suite 900, Washington DC 20036. Neither the American Society of Hematology nor the publisher is responsible for statements made by any editor or contributor. Statements, editorials, or opinions expressed in ASH Clinical News magazine do not necessarily represent official policy of the American Society of Hematology unless so stated. No responsibility is assumed by the American Society of Hematology or the Publisher for any injury or damage to persons or property as a matter of product liability, negligence or otherwise or from any use or operation of any methods, products, instructions or ideas contained in the material herein. Although all advertising material published in ASH Clinical News magazine is expected to conform to ethical (medical) standards, inclusion in this publication does not constitute a guarantee or endorsement by the American Society of Hematology or the Publisher of the quality or value of such product or of the claim made of it by its manufacturer. About the American Society of Hematology The American Society of Hematology (ASH) is the world’s largest professional society concerned with the causes and treatments of blood disorders. The mission of the Society is to further the understanding, diagnosis, treatment, and prevention of disorders affecting the blood, bone marrow, and the immunologic, hemostatic and vascular systems, by promoting research, clinical care, education, training, and advocacy in hematology. ASH Clinical News (ISSN 2375-8120) is published once per month by American Medical Communications, 630 Madison Avenue, 2nd Floor, Manalapan, NJ 07726. Periodicals postage is pending/paid at Manalapan, NJ and additional mailing offices. POSTMASTER: Send address changes to American Medical Communications, 630 Madison Avenue, 2nd Floor, Manalapan, NJ 07726. ©Copyright, 2018. ASH Clinical News 5