Contents

Overview 03 Bleeding management and VKAs : an overview Caroline Bsirini and Majed Refaai

07 PCC and reversal of oral anticoagulation Alexandra Bucko , Giorgia Saccullo , Joost van Veen and Mike Makris

Comparison 11 Comparison of FFP and 4F-PCC in warfarin reversal Jerrold Levy

DOACs 15 Direct oral anticoagulants and treatment of bleeding Jerrold Levy

Acute bleeding 18 Acute major bleeding and 4F-PCC Truman Milling

Pre-operative reversal 22 Pre-operative reversal of VKAs Chakri Gavva , Manasa Reddy and Ravi Sarode

Editor , Secondary Care Andrea Porter

Commissioning Editor Annabel De Coster

Commercial Director , Secondary Care & Business Health Jennifer Richardson

Managing Director Alex Beaumont

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