Annual Report-AGHI 2021-FINAL FOR WEB | Page 23

About the Testing

About the Testing

Genes are made up of DNA , which holds instructions that tell your body how to grow and function . DNA determines physical features , such as eye color and how tall you are .
DNA also affects the makeup of your internal tissues and organs , which can impact how quickly or slowly your body breaks down medications . In short , your genomic makeup can affect how well a medication works for you , your sensitivity to it , what dosage is least likely to cause side effects , and whether you might respond better to an entirely different medication .
That ’ s where pharmacogenomic testing comes in . It can help your health care providers better understand your body before prescribing a drug , thereby increasing the chances that your treatment will be safe and effective .
PHARMACOGENOMIC TESTING
Testing requires a blood sample , so that your DNA can be examined . Your physician and a pharmacist will review the results of your test before adding them to your electronic health record . Health care providers will be able to use this information to provide better care for you , now and in the future .
GENE
CYP2C19
COMMON DRUGS METABOLIZED
citalopram , escitalopram , pantoprazole , esomeprazole , omeprazole
CYP2C9 warfarin , ibuprofen , celecoxib , meloxicam
CYP2D6 amitriptyline , nortriptyline , tramadol , codeine , atomexetine
CYP3A5 tacrolimus
CYP4F2 warfarin
CYP2B6 efavirenz
SLCO1B1 simvastatin
DPYD capecitabine , fluorouracil
NAT2 hydralazine
NUDT15 azathioprine , mercaptopurine , thioguanine
TPMT azathioprine , mercaptopurine , thioguanine
UGT1A1 atazanavir , irinotecan
VKORC1 warfarin
* Not a comprehensive list aghi . org 21