AMINO AMSA-Indonesia EAMSC 2017 | Page 60

Appendix: Geometric Mean Titers in Test and Control Groups after each dose of Treatment
Geometric Mean Titre( 1 / dil) of DENV-1 neutralizing antibodies in Test and Control Groups
DENV 1
Dayan, et al
HSS, et al
Lanata, et al
Sabchareon, et al
Villar, et al
Leo, et al
( 2-11)
Leo, et al
( 12-17)
Baseline( Test Group)
41.4
15.3
17.4
42.8
74.2
5.33
6.47
Post Dose 2( Test Group)
436
119
125
120.7
276
-
-
Post Dose 3( Test Group)
267
151
179
146.1
320
56.6
28.5
Baseline( Control Group)
47.2
18.6
22.8
26.6
81.9
5.42
5.47
Post Dose 2( Control Group)
130
21
26.4
21.9
102
-
-
Post Dose 3( Control Group)
79.2
18.9
38.1
23.9
106
6.06
6.36
Geometric Mean Titre( 1 / dil) of DENV-2 neutralizing antibodies in Test and Control Groups
DENV 2
Dayan, et al
HSS, et al
Lanata, et al
Sabchareon, et al( 2012)
Villar, et al
Leo, et al
( 2-11)
Leo, et al
( 12-17)
Baseline( Test Group)
67
15.9
14.4
56.8
92.6
5.85
7.45
Post Dose 2( Test Group)
647
160
151
326
504
Post Dose 3( Test Group)
544
180
178
310
486
101
48.7
Baseline( Control Group)
68.3
18.6
18.2
43.7
100
5.17
5.54
Post Dose 2( Control Group)
137
17.9
17.3
43.5
114
Post Dose 3( Control Group)
132
16.3
21.6
52.2
133
5.88
6.17
Geometric Mean Titre( 1 / dil) of DENV-3 neutralizing antibodies in Test and Control Groups
DENV 3
Dayan, et al
HSS, et al
Lanata, et al
Sabchareon, et al( 2012)
Villar, et al
Leo, et al
( 2-11)
Leo, et al
( 12-17)
Baseline( Test Group)
81.9
15.6
16.4
31.5
85
6.24
6.84
Post Dose 2( Test Group)
1031
196
155
195
502
Post Dose 3( Test Group)
741
193
190
405
594
136
71.4
Baseline( Control Group)
94.7
15.9
21.8
28.7
88.8
5.95
6.83
Post Dose 2( Control Group)
227
15.9
26.6
24.6
108
Post Dose 3( Control Group)
140
16.3
36.2
48.9
121
6.54
8.1
Geometric Mean Titre( 1 / dil) of DENV-4 neutralizing antibodies in Test and Control Groups
DENV 4
Dayan, et al
HSS, et al
Lanata, et al
Sabchareon, et al( 2012)
Villar, et al
Leo, et al
( 2-11)
Leo, et al
( 12-17)
Baseline( Test Group)
15
9.92
8.12
28.1
37.2
5.64
5.83
Post Dose 2( Test Group)
346
110
144
159
305
Post Dose 3( Test Group)
432
114
184
155
276
104
79.2
Baseline( Control Group)
17.5
12.3
8.94
23.2
40.1
5.39
5.08
Post Dose 2( Control Group)
31.2
13.3
12.8
21.2
43.9
Post Dose 3( Control Group)
33.4
10.9
16.7
19.4
42.8
7.2
6.45