Fight Cancer with Something Inside
Aqdam Fauqo Al’Adli, Fah ri Somantri, Immanuella Yosephine Sirait, Laksmita Dwana, Pinka
Nurashri Setyati, Pretika Prameswari, Taufik Supriyana Trisaputra, Telaga Biroe
University of Trisakti, Faculty of Medicine, Jakarta Indonesia
Background:
According to American Cancer Society: Cancer is a group of diseases characterized by the
uncontrolled growth and spread of abnormal cells. If the spread is not controlled, it can result in
death. Cancer is caused by external factors such as tobacco, infectious organisms, and an
unhealthy diet.It is also caused by internal factors, such as inherited genetic mutations,
hormones, and immune conditions. There are more than fourteen million cases of new cancer
diagnosed in 2012 and the number has been gradually increasing since then. It proves us that
cancer is still one of the biggest challenge to overcome with in medical world, with no
specific treatment to fully cure and recover the patient up until today.
Amongst those newly discovered treatment for cancer, T-Cell Imunotherapy is one of them.
The said therapy can be divided into two approaches first is the use of gene-modified Tcell
receptors (TCRs) or use of or use of chimeric antigen receptors (CARs). Each one of the
approaches has it own benefit.
These differences are associated with the design of the two approaches that results in the
mechanism of work, thus bringing different effect in the growth of the cells. CARs are
recombinant receptors for antigens that retarget and eventually reprogram T-cell function.
TCRs are the physiological r X