AMINO AMSA-Indonesia EAMSC 2016 | Página 153

“CASPASE 1 INHIBITOR : THE PROMISING CELL SUICIDE INHIBITOR
FOR THE HIV THERAPY”
Ficky, Audrey Clarissa, Nathania Sutandi
Asian Medical Students’ Association - Faculty of Medicine University of Indonesia
HIV/AIDS has been the substantial health problem globally. In 2011, the number of
people suffering from HIV infection has reached 34 million worldwide where it increases with an
alarming rate, roughly around 2.7 million of new cases each year. In HIV progression to AIDS,
the hallmark of this process is massive loss of CD 4+ T cells, in which the process called pyroptosis
plays an important role. The underlying mechanism of pryoptosis is the activation of caspase 1 with
inflammasome pathway that leads to a vicious cycle of CD 4+ T cells deaths.
Antiretroviral therapy (ART) as the prime treatment for HIV/AIDS patient has shown to
be beneficial in delaying the progression of HIV to AIDS. However, it does not prevent the
progressive loss of CD 4+ T cells resulting in the resistancy of the drug. Mutation of HIV
antiviral has become one of the major problems in the treatment currently. Hence, we introduce
caspase 1 inhibitor as a new HIV therapy that works by inhibiting the inflammatory response,
thus decreasing CD4+ T cells death and slowing the progression of HIV to AIDS. One of the
most promising inhibitor is VX-765 in which IL-1β production can be hindered leading to the
extension of the patient life span.
In making this poster, we did a literature review on several medical journals and our
findings show that caspase 1 inhibitor is a promising key therapy in the future HIV treatment.
Keywords : HIV/AIDS, CD4+ T cell, cell to cell transmission, pyroptosis, caspase-1 inhibitor
Author
1. Ficky
Email : [e-mail]
Mobile phone : [phone]
Indonesia
2. Audrey Clarissa
Email : [e-mail]
Mobile phone : [phone]
Indonesia