A systematic review of stem cell-based neural regeneration as
post-ischemic stroke therapy for the development of stem cell
banking in Indonesia
Gabriele J. Kembuan1, Kevin J. Wijanarko1, Yusuf Azmi1
1
Faculty of Medicine, Universitas Airlangga, Indonesia
Introduction: The increasingly widespread use of human stem cells to treat conditions that
had no solution before, shows that the stem cell approach to medicine may be the key for
developing medical science in the future. One of the most common, yet difficult, conditions
plaguing many nations including Indonesia is the loss of function in patient after an ischemic
stroke event. It turns out that stem cell is now a viable approach in treating this morbidity, and
the authors aim to elaborate on both the theoretical basis of stem cell use, as well as
explaining the translation from bench to bedside by explaining about the available clinical
trials to date. The advantages and increasing prominence of umbilical cord blood derived
stem cells will also be discussed.
Methods: We systematically reviewed journals from databases such as PubMed, Cochrane,
and ScienceDirect, as well as government documents, to determine the viability and the best
approach to stem cell that is most suitable to the conditions in Indonesia.
Key Findings: We found that stem cell therapies are gaining increasing prominence and are
undergoing several clinical trials. We summarized from many studies that stem cells have
various properties that yield it viable as a treatment approach in stroke and CNS repair in
general, and that umbilical cord blood stem cells hold advantages in differentiation and HLA
antigenicity compared to other adult stem cells. We also found that the majority of clinical
trials on stroke yield satisfying results, and that the field of stem cell medication is rapidly
expanding, with a focus on umbilical cord stem cells. We suggest umbilical cord blood
banking as a form of feasible futuristic medicine approach by the Indonesian government.
Scope of research and areas for future research: Our study is a systematic review
feasibility study on translational medicine, health policy, and regenerative medicine. We
suggest future research on implementation, feasibility, and further clinical trials.
Correspondence;
[email] k_gabriele@outlook.com
[phone] +6289688884209