For her menopause journey . 1 , 2
For her transdermal preference . 1
For her range of menopause symptoms . 1 , 2
For her .
Medicine co-pack containing one pack of Estrogel ® ( estradiol hemihydrate ) plus one pack of Prometrium ® ( micronised progesterone ) for women with an intact uterus
EstrogelPro allows you to offer a hormone therapy that treats her range of menopause symptoms throughout her menopause journey . 1 , 2 With a personalised regimen that targets the underlying low estrogen , combined with micronised progesterone for women with an intact uterus , you can adapt the treatment to her needs along the way . 1 , 2 In the convenience of a single prescription .
PBS Information : These products are not available on the PBS .
Please review Product Information before prescribing , accessible at besins-healthcare . com . au / PI or 1800 BESINS ( 237 467 ), or by scanning the QR code :
Minimum Product Information Estrogel ( estradiol hemihydrate ) Indications : Hormone replacement therapy ( HRT ) for estrogen deficiency symptoms in postmenopausal women . Prevention of osteoporosis in postmenopausal women at high risk of future fractures who are intolerant of , or contraindicated for , other medicinal products approved for the prevention of osteoporosis . The lowest effective dose should be used for the shortest duration . Contraindications : Known , past or suspected breast cancer ; Known or suspected estrogen-dependent malignant tumours ( e . g . endometrial cancer ); Undiagnosed genital bleeding ; Untreated endometrial hyperplasia ; Previous or current venous thromboembolism ( e . g . deep venous thrombosis , pulmonary embolism ); Known thrombophilic disorders ( e . g . protein C , protein S , or antithrombin deficiency ); Active or recent arterial thromboembolic disease ( e . g . angina , myocardial infarction ); Acute liver disease , or a history of liver disease as long as liver function tests have failed to return to normal ; Known or suspected pregnancy ; Lactation ; Known hypersensitivity to the active substances or to any of the excipients ; Porphyria . Precautions : Appraisal of the risks and benefits should be undertaken at least annually . Refer to full Product information ( PI ) for conditions which require supervision during treatment with Estrogel . Treatment should be withdrawn if the following occur , jaundice or deterioration in liver function ; significant increase in blood pressure ; new onset of migraine type headache ; pregnancy . Caution : endometrial hyperplasia and carcinoma , breast cancer , ovarian cancer , venous thromboembolism , coronary artery disease ( CAD ), ischaemic stroke , thyroid function , elderly , paediatric use ( see full PI ). Interactions : use of concomitant skin medications , surface active agents or strong skin cleansers and detergents should be avoided at site of application , metabolism of estrogens may be increased by concomitant use of inducers of hepatic enzymes such as anticonvulsants ( phenobarbital , phenytoin , carbamezapine ) and anti-infectives ( rifampicin , rifabutin , nevirapine , efavirenz , ritonavir and nelfinavir ) and some herbal preparations ( St John ’ s wort ) reducing the effectiveness of estrogen , Estrogel as a transdermal administration might be less affected than other oral hormones by enzyme inducers . Pregnancy Category B3 ; not for use in lactation . Adverse Effects : headache , nausea , abdominal pain , breast swelling / pain , breast enlargement , dysmenorrhea , menorrhagia , metrorraghia , leucorrhooea , endometrial hyperplasia , weight gain ( increase or decrease ), water retention with peripheral edema ( see full PI ). Dosage and Administration : Estrogel should be used daily on a continuous basis . Estrogel as an estrogen only product is indicated only for women without a uterus . In women with an intact uterus it is recommended to add a progestogen for at least 12 days of each month . Although some women will respond to 1.25 g daily ( 1 pump ), the usual starting dose is 2.5 g per day ( 2 pumps ). If after one month of treatment , effective relief of menopausal symptoms is not obtained the dosage may be increased to a maximum of 5 g ( 4 pumps ) ( see full PI ). The lowest effective dose should be used for maintenance therapy . The optimal daily maintenance dose needs to be reevaluated regularly ( e . g . annually ). Estrogel should only be continued for as long as the benefit outweighs the risk . The correct dose of gel should be dispensed and applied to clean , dry , intact areas of skin e . g . on the arms and shoulders , and / or inner thighs . The area of application should be as large as possible . Refer to Full Product Information before prescribing .
Minimum Product Information Prometrium ( oral , micronised progesterone ) Indications : menstrual irregularities ; adjunctive use with an estrogen in postmenopausal women with an intact uterus . Contraindications : known allergy / hypersensitivity to progesterone or excipients ; severe hepatic dysfunction ; undiagnosed vaginal bleeding ; known missed abortion / ectopic pregnancy ; mammary / genital tract carcinoma ; thromboembolic disorders ; thrombophlebitis ; cerebral haemorrhage ; porphyria . Clinically Significant Precautions : not a treatment for premature labour ; not a contraceptive ; discontinue if unexplained visual loss / changes , proptosis , diplopia , papilloedema , retina vascular lesions or migraine ; use caution in conditions affected by fluid retention and history of depression , diabetes , hepatic dysfunction , migraine , photosensitivity and during lactation ; increased risk of breast cancer and venous thromboembolism with estrogen concomitant therapy ( refer estrogen PI ); may cause drowsiness ; may affect laboratory test results . Clinically Significant Interactions : caution with P450 enzyme inducers and inhibitors ; may increase antidiabetic medication ; bioavailability may be reduced by smoking and increased by alcohol abuse . Very Common and Common Adverse Effects : menstrual disturbances ; headache .
Dosage and Use : take capsules ( 100mg / 200mg ) orally , OD at bedtime without food . Hormone Replacement Therapy : 200 mg / d for 12d ( d15 – d26 ) of the cycle ; or 100mg can be given from d1 – d25 . Secondary amenorrhoea : 400mg / d for 10d . Ovulation disorders / anovulation : 200 – 300mg for 10d ( d17 – d26 , inclusive ).
References : 1 . Estrogel ® ( estradiol hemihydrate ) Product Information , updated 24 May 2021 . 2 . Prometrium ® ( micronised progesterone ) Product Information , updated 1 Feb 2022 . Estrogel ® and Prometrium ® are registered trademarks of Besins Healthcare . Besins Healthcare Australia Pty Ltd ABN 68 164 882 062 . Suite 5.02 , 12 Help Street , Chatswood NSW 2067 . Office phone ( 02 ) 9904 7473 . For medical information call 1800 BESINS ( 237 467 ). www . besins-healthcare . com . au EPR-EST-PRM-1775 September 2023