Acta Dermato-Venereologica Suppl 219 AbstractPsoriasis2018 | Page 37

Poster abstracts dataset of the Korean National Health Insurance Service database. Study population includes subjects who had undergone health screenings between January 2009 and December 2012. Patients who were diagnosed with psoriasis prior to the health screening or who were less than 20 years of age were excluded. This study investigated newly diagnosed patients with psoriasis (ICD-10 code, L40) by dermatologists among subjects during the follow-up period through the claim data. Result: Total 22,633,536 subjects were included and psoriasis newly developed in 399,461 subjects. Mean BMI among newly de- veloped psoriasis group (23.9 ± 3.25) was higher than non-psoriasis group (23.68 ± 3.27)(p < 0.0001). Mean WC of newly developed psoriasis group (81.21 ± 9.27) was higher than non-psoriasis group (79.99 ± 9.26) (p < 0.0001). BMI showed J-shaped association with the risk of psoriasis. Subjects with BMI over 30 had higher risk of psoriasis (HR 1.118, 95% CI 1.1–1.137). The risk of psoriasis increased in proportion to WC. Subjects with WC over 105 cm showed highest risk of psoriasis (HR 1.305, 95% CI 1.261–1.349) after adjusting confounding factors including BMI. The risk of psoriasis increased most in the male group with normal weight, abdominal obesity (HR 1.175, 95% CI 1.15–1.2). Conclusion: According to our study, the WC is more likely to affect the risk of psoriasis than obesity. Our s tudy supports the associa- tion between abdominal obesity and psoriasis, which increases awareness of the role of abdominal obesity in the pathogenesis and comorbidities of psoriasis. P080 CLINICAL CHARACTERIZATION OF PSORIATIC ARTHRITIS IN A MULTIDISCIPLINARY CARE MODEL OF PATIENTS WITH PSORIASIS Dalila Alejandra Lopez-Rodriguez Dermatologico Country Introduction: Psoriatic arthritis (PsA) is an inflammatory arthro- pathy that occurs in patients with Psoriasis (PsO). The frequency of PsA in patients with PsO has been estimated between 10–40%. The presentation and clinical course are variable, therefore, it is necessary to understand the clinical behavior, severity and as- sociated factors that condition functional impairment, disability and lost quality of life. Objective:To describe the clinical features of the ApS, in a mul- tidisciplinary PsO clinic. Methods: Prospective study, August 2016-february 2018, patients attending to Multidisciplinary Clinic for psoriasis in Dermatolo- gico Country were included. Results: A total of 53 participants were included, finding a preva- lence of psoriatic arthropathy of 58.5%. The median age was 42 years and 71% were female. Patients with ApS have higher frequency of DM2, metabolic syndrome and hepatic steatosis. However, the differences are not statistically significant, which could be a result of the sample size. According to the activity of PsO the most frequent presentation was plaque psoriasis in 67.7%. Median PASI was 5.4 (1.5, 16.4). Axial pre- sentation of ApS was observed in 51.6% and peripheral disease in 71%, enthesitis was found in 54.8% and dactylitis 16.1%. To determine the severity of PsA according DAS 28 score, we found 45.2% of patients presented severe activity. One hundred percent of the subjects with peripheral disease did not achieve low activity criteria of the disease measured by MDA. When calculating the tertiles of the HAQ instrument, it is possible to observe that 51.6% of patients presented severe deterioration in the quality of life. In the logistic regression model without adjustment, the presence of a severe DAS 28 is associated with an increase in the risk of deterioration in quality of life, with OR of 6.24 (1.74, 22.2). The presence of BMI >  27 is associated with an increase in the risk of deterioration in quality of life with OR of 6.53 (1.59, 26.8). When performing the adjusted multivariate 35 model, the only variables that were associated with severe de- terioration of quality of life were the presence of BMI >  27 and on the other side, pain, with BMI >  27 is the factor that mostly impairs the quality of life. Conclusions: Prevalence of PsA in this series of patients with skin or nail psoriasis was 58.3%. The 45.2% of patients showed severe activity and 51.6% severe deterioration in their quality of life, that leads to disability and limitation performing daily activities. An early diagnosis provides the possibility of appropriate treatment to improve function, quality of life and decrease the progression and complications of the disease. P081 TRIGGERING FACTORS IN CHILDHOOD PSORIASIS Iveta Dencheva 1 , Ivan Botev 2 , Lyubka Miteva 1 Dermatology clinic “Persenk”, 2 Department of Dermatology and Venere- ology, Medical University, Sofia, Bulgaria; Dermatology clinic “Persenk”, Sofia, Bulgaria 1 Introduction: Psoriasis is a chronic multisystem, inflammatory di- sease that occurs at any age. It represents about 4% of all dermato- sis observed in children. Approximately one third of all patients have onset of the disease under the age of 16. The most common triggering factors in children are stress, Koebner phenomenon, infections and seasonal change. Objectives: The aim of this study was to assess the most common triggering and precipitating factors of psoriasis among Bulgarien children. Materials and Methods: This study included 42 consecutively diagnosed children with psoriasis who presented in the Department of Dermatology and Venereology at Alexandrovska University Hospital, in Sofia, Bulgaria. The inclusion criteria were a clinical diagnosis of psoriasis and age under 18 years. Results: A total of 42 children with psoriasis were examined, 18 (42.85%) males and 24 (57.15%) females. The most frequent fac- tors precipitating psoriasis in our group of children were psycho- emotional stress in 16 (38.09%) cases. Koebner`s phenomenon was observed in 3 (7.14%) patients. In only two (4.76%) children triggering factors associated with psoriasis were infections. In 17 (40.47%) cases aggravating factors could not be identified. The influence of the season on disease activity could be determined in 25 (59.52%) patients. All of them showed worsening in winter and improvement in summer. Conclusion: The most frequent factors precipitating psoriasis in children revealed in this study, were stressful life events, Koebner phenomenon and infectious disease. Among patients who reported triggering factors, stress was the most common cause. The study showed that psoriasis in children relapses and worsens mainly in winter season. P082 QUALITY OF CARE FOR PSORIASIS IN THE PAST 12 YEARS – RESULTS FROM A SERIES OF NATIONWIDE HEALTH CARE STUDIES IN GERMANY Matthias Augustin Institute for Health Services Research in Dermatology Introduction: In Germany, the quality of health care for psoriasis was very critical in 2005. Most patients lacked of sufficient care and there was only a minor proportion receiving systemic drugs. In the mean time, there has been conducted a national psoriasis program in order to improve the quality of psoriasis care, inclu- ding development of an evidence-based guideline, a consensus of treatment goals, the invention of a “culture of measurement” and consented national goals for psoriasis care. These measures were supported by the establishment of 30 regional psoriasis networks involving more than 800 dermatologists. Objectives: (1) Presentation of the very recent results on the health care situation of patients with psoriasis vulgaris in dermatological Acta Derm Venereol 2018