Acta Dermato-Venereologica 99-12CompleteContent | Page 35

SHORT COMMUNICATION Acquired Regional Multiple Plaque-like Glomangiomyoma in the First Web Space of the Left Hand Xu-Yue ZHOU # , Chao LUAN # , Chen-Pu ZHU, Rong LI, Wei ZHANG* and Kun CHEN* Institute of Dermatology, Jiangsu Key Laboratory of Molecular Biology for Skin Disease and STIs, Chinese Academy of Medical Sciences & Peking Union Medical College, 12 JiangWangMiao Street, Nanjing Jiangsu, 210042, China. *E-mails: [email protected]; [email protected] # These authors contributed equally. Accepted Aug 26, 2019; E-published Aug 27, 2019 Glomus tumours are benign vascular hamartomas arising from the glomus body in the reticular dermis. They can be classified as solitary or multiple forms, with the latter being subdivided into regional and disseminated types. Glomangiomyomas are the least common histological type of glomus tumour (1). We describe here a case of ac- quired regional multiple plaque-like glomangiomyoma. CASE REPORT A 20-year-old Chinese man presented with an 8-year history of multiple progressively asymptomatic nodules on his left hand. Physical examination revealed a plaque- like, bluish lesion, with overlying coalescent, point to horsebean-sized, ranging from 2 mm to 20 mm, dull red-to-tan papules and nodules on the first web space of the left hand (Fig. 1a). Ultrasound scans revealed hypoechoic solid masses in the subcutaneous region, with no obvious blood flow signal (Fig. 1b). A skin biopsy specimen revealed a well-demarcated tumour in the dermis, which comprised uniform eosinophilic cyto- plasmic cells, with round, large hyperchromatic nuclei. Around large vessels there was a gradual transition from glomus cells to spindle-shaped smooth muscle cells with long blunt-ended nuclei (Fig. 1c). Immunohistochemical examination revealed intensely positive reactions for smooth muscle actin (SMA) in glomus cells (Fig. 1d), desmin in muscle bundles (Fig. 1e) and CD31 in blood 1188 Fig. 1. (a) Multiple grouped dull red-to-tan papules and nodules coalescing into bluish plaques on the first web space of the patient’s left hand. (b) The hypoechoic mass without obvious blood flow signal. (c) A gradual transition from glomus cells to spindle-shaped smooth muscle cells with long blunt- ended nuclei around vascular spaces (haematoxylin-eosin (HE); ×40). (d) The homogeneous eosinophilic cytoplasmic glomus cells stained positive for smooth muscle actin (SMA) (×40). (e) Some muscle bundles stained positive for desmin, but negative in glomus cells (×40). (f) Some blood vessels stained positive for CD31 (×40). (g) The homogeneous eosinophilic cytoplasmic cells stained negative for P63 (×40). doi: 10.2340/00015555-3308 Acta Derm Venereol 2019; 99: 1188–1189 This is an open access article under the CC BY-NC license. www.medicaljournals.se/acta Journal Compilation © 2019 Acta Dermato-Venereologica.