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CLINICAL REPORT ActaDV ActaDV Advances in dermatology and venereology Acta Dermato-Venereologica
Association Between Premature Hair Greying and Metabolic Risk Factors: A Cross-sectional Study
Seung Hwan PAIK 1 – 4, Sihyeok JANG 1, Hee-Kyung JOH 5, 6, Chun Soo LIM 7, BeLong CHO 8 – 10, Ohsang KWON 1 – 3 and Seong Jin JO 1 – 3
1
Department of Dermatology, 5 Department of Medicine and 10 Institute on Aging, Seoul National University College of Medicine, 2 Institute of Human-Environment Interface Biology and 9 Advanced Institutes of Convergence Technology, Seoul National University, 3 Laboratory of Cutaneous Aging and Hair Research, Biomedical Research Institute and 8 Department of Family Medicine and Health Promotion Center, Seoul National University Hospital, 4 Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, 6 Department of Family Medicine, Seoul National University Health Service Center, and 7 Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea
The association of hair greying with metabolic syndrome is not well known, while association with obesity and coronary artery disease has been suggested. A cross-sectional study was conducted to identify an association between premature hair greying and metabolic risk factors. Of the 1,929 young healthy subjects( 1,067 men and 862 women), 704( 36.4 %) were categorized in the premature hair greying group. Waist circumference( means of non-premature hair greying vs. premature hair greying, 74.3 vs. 76.3 cm; p < 0.001), systolic( 109.2 vs. 111.7 mmHg; p < 0.001) and diastolic( 65.0 vs. 66.2 mmHg; p = 0.003) blood pressures, and fasting blood sugar( 90.8 vs. 91.6 mg / dl; p = 0.013) were higher and serum high-density lipoprotein cholesterol( 68.1 vs 65.4 mg / dl; p < 0.001) was lower in premature hair greying group. Multivariate logistic regression analysis showed that metabolic risk factors ≥ 2 was independently associated with premature hair greying after controlling for confounding factors( odds ratio 1.725; p = 0.036). The present study revealed an association between premature hair greying and metabolic risk factors.
Key words: hair greying; premature hair greying; metabolic syndrome; metabolic risk factors.
Accepted May 22, 2018; Epub ahead of print May 24, 2018 Acta Derm Venereol 2018; 98: 748 – 752.
Corr: Seong Jin Jo, Department of Dermatology, Seoul National University College of Medicine, 101 Daehangno, Chongno-gu, 03080 Seoul, Korea. E-mail: sj. jo @ snu. ac. kr
Hair greying( canities) is a natural age-related occurrence( 1). Since everyone develops grey hair with age, it is not considered a disease. Even when a person develops grey hair at a young age, it is thought of as a cosmetic, not a medical, condition. However, as the chances of developing a disease increase with age, many studies have postulated that hair greying could be a predictor of some geriatric diseases. For example, some studies have revealed an association between hair greying and coronary artery disease( CAD)( 2 – 4).
In our previous study, we found that premature hair greying( PHG) is associated with family history of PHG, smoking and obesity( 5). Among these factors, smoking
SIGNIFICANCE
This study presented an association between premature hair graying and metabolic risk factors in young Koreans. Waist circumference, blood pressure, and fasting blood sugar were higher and serum high-density lipoprotein cholesterol was lower in subjects with premature hair graying. The prevalence of subjects who had two or more metabolic risk factors was higher in subjects with premature hair graying than those without. It postulates that premature hair graying can be considered as a clinical marker for evaluating patients at risk for metabolic syndrome.
and obesity are risk factors for CAD. The National Cholesterol Education Program’ s Adult Treatment Panel III report( ATP III) viewed CAD as the primary outcome of metabolic syndrome( 6), which is a constellation of interrelated risk factors of metabolic origin( metabolic risk factors), such as obesity, dyslipidaemia and hypertension( 7). Metabolic syndrome could induce precocious ageing( 8). However, an association between hair greying and metabolic syndrome has seldom been studied.
The aim of the present study was to determine if there is an association between PHG and metabolic risk factors, after adjustment for potential confounders. PHG was considered as the presence of grey hair under the age of 30 years in this study, since hair greying usually begins in the fourth decade of life( 1). Data about already known associated risk factors, such as family history of PHG and smoking history, were collected using questionnaires. Biochemical and anthropometric parameters related to the metabolic profile were measured, and their association with PHG was analysed.
METHODS Study design
Healthy participants undergoing regular medical check-ups were recruited at the Center for Health Promotion and Optimal Aging of Seoul National University Hospital, between March 2015 and February 2016. To be included in the study, participants had to be healthy with no acute or chronic disease, aged between 20 and 29 years, and consent to participate in the study. Subjects were excluded if they had an existing hypopigmentary disorder, or had doi: 10.2340 / 00015555-2974 Acta Derm Venereol 2018; 98: 748 – 752
This is an open access article under the CC BY-NC license. www. medicaljournals. se / acta Journal Compilation © 2018 Acta Dermato-Venereologica.