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Lymphomatoid Papulosis (LyP) Associated with Diffuse Large B-cell Lymphoma and Cutaneous
Anaplastic Large Cell Lymphoma: LyP as a Haematological Malignancy-related Dermadrome
Fumi MIYAGAWA, Hiroshi IIOKA and Hideo ASADA
Department of Dermatology, Nara Medical University School of Medicine, 840 Shijo, Kashihara, Nara 634-8522, Japan. E-mail: fumim@
naramed-u.ac.jp
Accepted May 22, 2018; Epub ahead of print May 24, 2018
Lymphomatoid papulosis (LyP) is a cutaneous CD30 +
lymphoproliferative disorder (LPD) characterized by
chronic recurrent, self-healing papulonodular eruptions
and the histological features of malignant lymphoma
(1). Patients with LyP are at increased risk of develo-
ping lymphoma, particularly mycosis fungoides (MF)
and anaplastic large cell lymphoma (ALCL) (1). We
describe here an unusual case, in which LyP occurred in
a patient with diffuse large B-cell lymphoma (DLBCL)
and primary cutaneous ALCL (pcALCL). No cases of
LyP associated with both pcALCL and DLBCL have
been reported previously (according to a PubMed search
using the terms “lymphomatoid papulosis”, “diffuse large
B-cell lymphoma”, and “cutaneous anaplastic large cell
lymphoma”).
CASE REPORT
A 79-year-old man presented with a 1.5-cm red tumour on his left
arm, which grew over a 1-month period (Fig. 1a). Multiple swol-
len lymph nodes (LN) were seen on computed tomography (CT)
of the chest 16 months previously, and a cervical LN biopsy was
performed. A histopathological examination of the LN revealed
large atypical cells, which expressed CD20 and immunoglobulin
kappa mRNA, surrounded by histiocytes and lymphocytes. He had
SHORT COMMUNICATION
Fig. 1. (a) Tumour on the left upper arm. (b) Histopathological examination demonstrated diffuse cohesive dermal infiltrates of large pleomorphic lymphoid
cells (haematoxylin and eosin staining; ×20). (c) Higher magnification of (b) (×200). (d) Higher magnification of (b) (×400). High-power image of atypical
T-cells is shown. (e) Immunohistochemistry detected diffuse positivity for CD30 (×200). (f) Two nodules on the left upper arm. (g) Histopathological
examination demonstrated epidermotropic infiltrates of small to medium-sized lymphocytes with atypical nuclei. A Pautrier’s microabscess was detected
(haematoxylin and eosin staining; ×100). (h) Higher magnification of (g) (×400). (i) Immunohistochemistry demonstrated that the tumour cells were
positive CD30 (×100). (j) Clusters of recurrent, self-healing, nodules on the left upper arm.
This is an open access article under the CC BY-NC license. www.medicaljournals.se/acta
Journal Compilation © 2018 Acta Dermato-Venereologica.
doi: 10.2340/00015555-2973
Acta Derm Venereol 2018; 98: 799–800