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INVESTIGATIVE REPORT
Degree of Skin Barrier Disruption Affects Lipid Organization in
Regenerated Stratum Corneum
Tineke BERKERS, Dani VISSCHER, Gert S. GOORIS and Joke A. BOUWSTRA
Department of Drug Delivery Technology, Cluster BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden,
The Netherlands
Previously, a skin barrier repair model was developed
to examine the effect of formulations on the lipid pro-
perties of compromised skin. In this model, the lipid
organization mimics that of several skin diseases with
impaired skin barrier and less dense lateral lipid orga-
nization. In addition, parakeratosis was occasionally
observed. The present study investigated whether the
extent of initial barrier disruption affects lipid orga