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ADVATE has over 15 years of treatment experience in the real world and provides clinically proven bleed protection * for patients with hemophilia A . 1
Proven clinical record 2
Extensively studied — 15 years
The most widely used FVIII product , with 15 prospective studies 2 , 3 with 33 billion IUs sold globally 2
REAL LIFE . REAL BLEED PROTECTION .* AdvateRealLife . com / HCP
WARNINGS & PRECAUTIONS ( continued ) Neutralizing Antibodies
Neutralizing antibodies ( inhibitors ) have been reported following administration of ADVATE predominantly in previously untreated patients ( PUPs ) and previously minimally treated patients ( MTPs ). Monitor all patients for the development of factor VIII inhibitors by appropriate clinical observation and laboratory testing . If expected plasma factor VIII activity levels are not attained , or if bleeding is not controlled with an expected dose , perform an assay that measures factor VIII inhibitor concentration .
ADVERSE REACTIONS
• Serious adverse reactions seen with ADVATE are hypersensitivity reactions , including anaphylaxis , and the development of high-titer inhibitors necessitating alternative treatments to factor VIII .
• The most common adverse reactions observed in clinical trials (> 5 % of subjects ) were pyrexia , headache , cough , nasopharyngitis , arthralgia , vomiting , upper respiratory tract infection , limb injury , nasal congestion , and diarrhea .
Please see the following page for the Brief Summary of the ADVATE full Prescribing Information . For Full Prescribing Information , visit www . advatepro . com .
REFERENCES : 1 . ADVATE Prescribing Information . 2 . Takeda data on fi le . 3 . Grillberger L , Kreil TR , Nasr S , Reiter M . Emerging trends in plasma-free manufacturing of recombinant protein therapeutics expressed in mammalian cells . Biotechnol J . 2009 ; 4 ( 2 ): 186-201 .
Copyright © 2020 Takeda Pharmaceutical Company Limited . 300 Shire Way , Lexington , MA 02421 . 1-800-828-2088 . All rights reserved . TAKEDA and the TAKEDA logo are trademarks or registered trademarks of Takeda Pharmaceutical Company Limited . ADVATE is a registered trademark of Baxalta Incorporated , a Takeda company . US-ADV-0121v1.0 05 / 20