Page 20 | ABUSE Magazine
Danger sign: The brightly colored packets of Spice and K2 have all-ages appeal
Most of the best known research chemicals are structural analogues of tryptamines or phenethylamines, but there are also many other completely unrelated chemicals that can be considered as part of the group. It is very difficult to determine psychoactivity or other pharmaceutical properties of these compounds based strictly upon structural examination. Many of the substances have common effects while structurally different and vice versa( see also SAR paradox). As a result of no real official naming for some of these compounds, as well as regional naming, this can all lead to( and is anecdotally known to have led to) potentially hazardous mix ups for users.
Source: Wikipedia. org
While through recent history most designer drugs had been either opioids, hallucinogens, or anabolic steroids, the range of possible compounds is limited only by the scientific and patent literature, and recent years have been characterised by a broadening of the range of compounds sold as designer drugs. These have included a wide variety of designer stimulants such as geranamine, mephedrone, MDPV and desoxypipradrol, several designer sedatives such as methylmethaqualone and premazepam, and designer analogues of sildenafil( Viagra), which have been reported as active compounds in“ herbal” aphrodisiac products. Designer cannabinoids are another recent development, with two compounds JWH-018 and( C8)-CP 47,497 initially found in December 2008 as active components of“ herbal smoking blends” sold as legal alternatives to marijuana, and subsequently a growing range of synthetic cannabinoid agonists have continued to appear, including by 2010 novel compounds such as RCS-4, RCS-8, and AB-001, which had never been reported in the literature, and appear to have been invented by designer drug manufacturers themselves. The relative market saturation with the wide variety of opioid and hallucinogenic drugs already available has slowed the emergence of new compounds in these areas, as well as the continuing trickle of novel hallucinogens and dissociatives such as methoxetamine and 2C. Another novel development is the use of research ligands for cosmetic rather than strictly recreational purposes, such as grey-market internet sales of the non-approved alpha-melanocyte-stimulating hormone tanning drugs known as melanotan peptides.
abusemagazine. org
Common designer drugs