“ Most previous lung cancer studies have not separated data of smokers from non-smokers, which has limited insights into potential causes in those patients,” Landi adds.“ We have designed a study to collect data from never-smokers around the world and use genomics to trace back what exposures might be causing these cancers. This is an urgent and growing global problem that we are working to understand.”
Related Links
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Research in Context: Detecting Cancer Advancing Molecular Insights into Cancer Earlier Smoking Cessation May Improve Lung Cancer Survival Genomic Origins of Lung Cancer in Never Smokers Genomic Analysis of 33 Cancer Types Completed Lung Cancer Lung Cancer Screening Cancer Stat Facts: Lung and Bronchus Cancer Sherlock-Lung Study
References
The mutagenic forces shaping the genomes of lung cancer in never smokers. Díaz-Gay M, Zhang T, Hoang PH, Leduc C, Baine MK, Travis WD, Sholl LM, Joubert P, Khandekar A, Zhao W, Steele CD, Otlu B, Nandi SP, Vangara R, Bergstrom EN, Kazachkova M, Pich O, Swanton C, Hsiung CA, Chang IS, Wong MP, Leung KC, Sang J, McElderry JP, Hartman C, Colón-Matos FJ, Miraftab M, Saha M, Lee OW, Jones KM, Gallego-García P, Yang Y, Zhong X, Edell ES, Santamaría JM, Schabath MB, Yendamuri SS, Manczuk M, Lissowska J, Świątkowska B, Mukeria A, Shangina O, Zaridze D, Holcatova I, Mates D, Milosavljevic S, Kontic M, Bossé Y, Rothberg BEG, Christiani DC, Gaborieau V, Brennan P, Liu G, Hofman P, Yang L, Nowak MA, Shi J, Rothman N, Wedge DC, Homer R, Yang SR, Pesatori AC, Consonni D, Lan Q, Zhu B, Chanock SJ, Choi J, Alexandrov LB, Landi MT. Nature. 2025 Jul 2. doi: 10.1038 / s41586-025-09219-0. Online ahead of print. PMID: 40604281.
Funding
NIH’ s National Cancer Institute( NCI) and National Institute of Environmental Health Sciences( NIEHS); David and Lucile Packard Foundation; Sanford Stem Cell Institute at the University of California San Diego; European Union NextGenerationEU funds.
Source: https:// www. nih. gov / news‐events / nih‐research‐matters / factors‐linked‐lung‐cancer‐never‐smokers