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LSDR – The Rare Disease Registry program ( including Gaucher , Fabry , MPS I , and Pompe diseases ) is a multi-center , international , longitudinal , observational , and voluntary program that tracks the natural history and treatment outcomes of patients with these rare diseases , both treated and not treated . Principal investigator : Shelley Hall , MD
LVAD REFERRAL PATTERNS - On the origin of gender and racial disparities in advanced heart failure : A single-center retrospective analysis to distinguish referral bias versus management difference in access to advanced cardiothoracic heart failure therapies . Principal investigator : Robert L . Gottlieb , MD , PhD .
MEDTRONIC DT PAS - The HeartWare™ HVAD™ destination therapy ( DT ) post approval study ( PAS ) to further confirm safety and effectiveness of the HeartWare Ventricular Assist Device System ( HVAD System ) when used as intended , in “ real-world ” clinical practice . Principal investigator : Dan M . Meyer , MD .
MEDTRONIC TAVR IN LOW RISK PATIENTS / LOW RISK CAS – A study evaluating transcatheter aortic valve replacement ( TAVR ) in patients with the Medtronic TAVR Replacement System in patients at low risk for surgical aortic valve replacement ( SAVR ). Principal investigator : Robert Stoler , MD .
METEORIC - A double-blind , randomized , placebocontrolled , multi-center study to assess the effect of omecamtiv mecarbil on exercise capacity in subjects with heart failure with reduced ejection fraction and decreased exercise tolerance . Principal investigator : Amarinder Bindra , MD .
MOMENTUM 3 CAP - The purpose of this study is to evaluate the safety and effectiveness of the HeartMate 3 LVAS by demonstrating non-inferiority to the HeartMate 2 LVAS when used for the treatment of advanced , refractory , left ventricular heart failure . Principal investigator : Shelley Hall , MD .
MOTR – The purpose of this study is to assess the use of donor-derived cell-free DNA in multi-organ transplant rejection detection . Principal investigator : Timothy Gong , MD .
NEUROCOG - Neurocog TAVR is a prospective evaluation of neurocognition in patients undergoing transcatheter aortic valve replacement : periprocedural changes and predictors of improvement . Principal investigator all local sites : Potlouri , MD . Lead investigator Dallas site : Robert Stoler , MD .
NODE 303 – This study evaluates the safety of selfadministered Etripamil nasal spray for paroxysmal supraventricular tachycardia . Principal investigator : Praveen Rao , MD .
NUPULSE CV IVAS – This is a clinical feasibility study to evaluate ambulatory counterpulsation for the treatment of advanced heart failure . Principal investigator : Dan M . Meyer , MD .
ONYX ONE CLEAR – This study is designed to evaluate the clinical safety of the Resolute Onyx stent with use of one-month DAPT in subjects deemed at high risk for bleeding and / or medically unsuitable for more than one-month DAPT treatment . Principal investigator : James Choi , MD .
PARAGLIDE HF - A multi-center , randomized , double-blind , double-dummy , parallel group , active controlled eight-week study to evaluate the effect of sacubitril / valsartan ( LCZ696 ) versus valsartan on changes in NT-proBNP and safety and tolerability of in-hospital initiation of LCZ696 compared to valsartan in HFpEF patients with acute decompensated heart failure ( ADHF ) who have been stabilized during hospitalization ( PARAGLIDE- HF ). Principal investigator : Shelley Hall , MD .
PCR – The Preventive Cardiology Registry . Principal investigator : Peter McCullough , MD .
PGD NATIONAL REGISTRY - Primary Graft Dysfunction International Consortium . Principal investigator : Shelley Hall , MD .
PREDICTORS OF EARLY ELEVATION – This study looks at the predictors of intermediate / high AlloSure scores outside of acute cellular rejection , antibodymediated rejection and / or graft failure . Principal investigator : Sandra Carey , PhD .
PRESERVED-HF - This study evaluates the effects of dapagliflozin on biomarkers , symptoms and functional status in patients with PRESERVED ejection fraction heart failure . Principal investigator : Cesar Guerrero-Miranda , MD .
PROTECT REGISTRY - PROSPERA TEST EVALUATION IN CARDIAC TRANSPLANT ( PROTECT ) - The PROTECT registry is an observational longitudinal , multicenter study observing patients undergoing heart transplant for whom Prospera testing is part of routine clinical care , who are enrolled within 60 days of heart transplantation . Principal investigator : Amit Alam , MD .
Baylor Scott & White Heart and Vascular Hospital | Clinical Trials and Research