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HORIZON – A randomized double-blind , placebocontrolled , multi-center trial assessing the impact of lipoprotein ( a ) lowering with TQJ230 on major cardiovascular events in patients with established cardiovascular disease : HORIZON outcomes study . Principal investigator : Cara East , MD .
INCEPTION - A randomized , controlled , multicenter , open-label trial comparing a hospital postdischarge care pathway involving aggressive LDL-C management that includes inclisiran with usual care versus usual care alone in patients with a recent acute coronary syndrome ( VICTORION-INCEPTION ). Principal investigator : Cara East , MD .
NN-OBESITY STUDY - An investigation of the efficacy and safety of NNC0165-1875 as add-on to semaglutide for weight management in subjects with obesity . Principal investigator : Priscilla L . Hollander , MD .
ON-X PROACT - On-X ® valve using low dose anticoagulation . Principal investigator : Robert Smith , MD .
PERSPECTIVE - A multi-center , randomized , doubleblind , active-controlled study to evaluate the effects of LCZ696 compared to valsartan on cognitive function in patients with chronic heart failure and preserved ejection fraction . Principal investigator : Cara East , MD .
PREVENT - A randomized double-blind , placebocontrolled , multi-center trial , assessing the impact of inclisiran on major adverse cardiovascular events in participants with established cardiovascular disease ( VICTORION-2 PREVENT ). Principal investigator : Cara East , MD .
VESALIUS - A double-blind , randomized , placebocontrolled , multi-center study to evaluate the impact of evolocumab on major cardiovascular events in patients at high cardiovascular risk without prior myocardial infarction or stroke - VESALIUS Study . Principal investigator : Cara East , MD .
WAVE - Prospective , randomized , controlled , multi-center study comparing the merit WRAPSODY endovascular stent graft to percutaneous transluminal angioplasty for treatment of venous outflow circuit stenosis or occlusion in hemodialysis patients . Principal investigator : Stephen Hohmann , MD .
BAYLOR SCOTT & WHITE RESEARCH INSTITUTE DALLAS SITE
ABBOTT SKYPOINT 48 - A study to evaluate the safety and effectiveness of the ABT NG DES 48 in improving coronary artery luminal diameter in subjects with coronary artery disease ( CAD ) due to de novo native coronary artery long lesions . Principal investigator : James Choi , MD .
ACURATE - Acurate transfemoral aortic valve system is compared to other commercially available valves that can be delivered without open heart surgery . Principal investigator : Robert Stoler , MD .
AGENT™ – The purpose of the trial is to assess the safety and effectiveness of the Agent™ Paclitaxel Coated PTCA Balloon Catheter compared to balloon angioplasty ( POBA ) in patients with in-stent restenosis ( ISR ) of a previously treated lesion of up to 26 mm in length ( by visual estimate ) in a native coronary artery 2.0 mm to 4.0 mm in diameter . Principal investigator : Robert Stoler , MD .
AIM Higher - Assessment of implantable cardiac contractility modulation ( CCM ) in the heart failure group with higher ejection fraction . This study aims to evaluate the efficacy and safety of CCM therapy in patients with symptomatic heart failure and ejection fraction in the range of 40 to 60 %. Principal investigator : Amarinder Bindra , MD .
ALL-IN – A study to evaluate if Tocilizumab will , when given with standard anti-rejection medicines , lead to better heart transplantation outcomes at one year after the transplant , with less rejection , less development of unwanted antibodies , and better heart function . Principal investigator : Shelley Hall , MD .
ALLO MAP PATIENT EXPERIENCE STUDY - A single-center survey study to compare the postheart transplant patient ’ s experience of having two different modalities of testing completed : endomyocardial biopsy ( EMB ) and Allomap ® testing . This is to check for graft rejection parameters and to assess the differences in terms of patient satisfaction via the Generalized Anxiety Disorder 7 item scale ( GAD-7 ) validated instrument , pain experience via the Polyclinic pain scale instrument , and questions about any adverse events . Principal investigator : Aayla Jamil , MPH .
Baylor Scott & White Heart and Vascular Hospital | Clinical Trials and Research