2020 UAB Cardiovascular Institute Annual Report CVI Annual Report 2019-2020 6 | Page 36

CLINICAL GOALS 2020
UAB Cardiology established a cardiology oncology
program that unites cardiologists, oncologists, and
clinical researchers to help improve cardiovascular
health for patients undergoing surgery, chemotherapy,
and radiation for cancer. As an important new concept
in cardiac care, the UAB cardio-oncology program
identifies the potential risk associated with some
cancer therapies and provides early intervention to
prevent long-term cardiovascular damage. Our cardio-
oncology care spans from the time of diagnosis through
survivorship, optimizing the cardiovascular care of
cancer patients. The program currently consists of
three physicians, one nurse practitioner, and one nurse
coordinator. Our cardio-oncology program has expanded
in three important areas of clinical volume, research, and
education, which complements UAB Medicine’s mission.
HIGHLIGHTS
• Add an inpatient cardio-oncology consult service to enhance the cardiovascular care provided by our inpatient
hem-onc service and provide better continuity when patients are discharged
• Earn designation through the Amyloid Research Consortium (ARC)
• Expand volume of telemedicine appointments
RESEARCH IN CARDIO-ONCOLOGY
• Received grant funding for pilot project for cardiovascular monitoring of patients treated with immunotherapy
• Began 2 clinical trials (MIGHTY, UPBEAT) in cardio-oncology at UAB
EDUCATION IN CARDIO-ONCOLOGY
Cardio-oncology providers left to right, are Garima Arora, MD, Carrie
Lenneman, MD, and Riem Hawi, MD.
• UAB cardio-oncology clinics at The Kirklin Clinic of UAB Hospital, seeing patients 3 half-days per week
• Improved access: The average wait time for an oncology patient to see cardiology was reduced from 21 days to
fewer than 9 days. Same-day appointments often are provided when needed.
• Over 350 cardio-oncology visits at The Kirklin Clinic between January 2018 and September 2018
• Added an NP to help with return cardio-oncology visits
• Telemedicine visits for return cardio-oncology patients to reduce travel burden
• New collaborative cardiovascular monitoring plans for CML patients treated with tyrosine kinase inhibitors
INTEGRATED CARE MODEL
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UAB Cardiovascular Institute Annual Report
CARDIO-ONCOLOGY
• Training curriculum for cardiology fellows in cardio-oncology, with weekly clinic rotations and didactics
• Mentoring fellows in cardio-oncology research projects
SELECTED PUBLICATIONS
• Lenneman CG, Sawyer DB. Cardio-Oncology: An Update on Cardiotoxicity of Cancer-Related Treatment.
Circulation Research. 2016 Mar 18;118(6):1008-20. PMID: 26987914
• Lenihan DJ, Anderson SA, Lenneman CG, Brittain E, Muldowney JAS 3rd, Mendes L, Zhao PZ, Iaci J, Frohwein
S, Zolty R, Eisen A, Sawyer DB, Caggiano AO. A Phase I, Single Ascending Dose Study of Cimaglermin Alfa
(Neuregulin 1β3) in Patients With Systolic Dysfunction and Heart Failure. JACC Basic Transl Sci. 2016 Dec
26;1(7):576-586. PMID: 28235789
• Ryzhov S, Matafonov A, Galindo CL, Zhang Q, Tran TL, Lenihan DJ, Lenneman CG, Feoktistov I, Sawyer DB.
ERBB Signaling Attenuates Proinflammatory Activation of Nonclassical Monocytes. Am J Physiol Heart Circ
Physiol. 2017 May 1;312(5):H907-H918. PMID: 28235789
• Bolli R, Hare JM, Henry TD, Lenneman CG, March KL, Miller K, Pepine CJ, Perin EC, Traverse JH, Willerson
JT, Yang PC, Gee AP, Lima JA, Moyé L, Vojvodic RW, Sayre SL, Bettencourt J, Cohen M, Ebert RF, Simari RD;
Cardiovascular Cell Therapy Research Network (CCTRN). Rationale and Design of the SENECA (StEm cell
iNjECtion in cAncer survivors) Trial. Am Heart J. 2018 Jul;201:54-62. PMID: 29910056
• Miao J, Huang S, Su YR, Lenneman CA, Wright M, Harrell FE, Sawyer DB, Lenihan DJ. Effects of endogenous
serum neuregulin-1β on morbidity and mortality in patients with heart failure and left ventricular systolic
dysfunction. Biomarkers. 2018 Aug 17:1-5. PMID: 29871526
• Burkhart T, Keith MC, Lenneman C, Fernando RR. Bortezomib-Induced Cardiac Tamponade in a 49-Year-Old
Man.Texas Heart Inst J. 2018, Aug, Vol. 45:4 260-263.
• Hayek SS, Ganatra S, Lenneman C, Scherrer-Crosbie 4, Leja M, Lenihan DJ, Yang E, Ryan TD, Liu J, Carver J,
Mousavi N, O’Quinn R, Arnold A, Banchs J, Barac A, Ky B. Preparing the Cardiovascular Workforce to Care for
Oncology Patients. J Am Coll Cardiol. 2019 May 7;73(17):2226-2235.
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