2020 UAB Cardiovascular Institute Annual Report CVI Annual Report 2019-2020 6 | Page 10

UAB’s Structural Heart and Valve Program has expertise in all aspects of valve-related surgery, including procedures treating infectious disease, stenotic and insufficient valves, and congenital valvular heart disease. Both standard open and minimally invasive valve repair/replacement (transcatheter and robotic approaches) procedures are performed. In addition to transcatheter aortic valve replacement (TAVR), we offer aortic and mitral valve treatment, valvuloplasty, valve replacement surgery, valve-sparing aortic root replacement, and the Ross procedure. Transcatheter mitral valve and tricuspid valve repair techniques also are available. UAB performed more than 4,200 valve procedures from 2014 to 2019 and received a high-performing rank for aortic valve surgery care in 2019 from USNWR. STS COMPOSITE QUALITY RATINGS 2019 UAB STS OVERALL COMPOSITE QUALITY RATINGS Isolated AVR HH CABG + AVR HHH MVRR HHH CABG + MVRR HHH UAB PARTICIPANT SCORE STS COMPOSITE QUALITY RATING 96.2% Not statistically different than the STS mean 95.4% Significantly higher than the STS mean 93.6% Significantly higher than the STS mean 92.8% Significantly higher than the STS mean TRANSCATHETER AORTIC VALVE REPLACEMENT (TAVR) UAB’s transcatheter aortic valve replacement (TAVR) program began in August 2012 as the first of its kind in Alabama and features a multidisciplinary team of 4 cardiovascular surgeons, 5 interventional cardiologists, advanced practitioners, nurses, psychologists, and members of a quality team, all of whom collaborate to provide comprehensive, quality, and patient-centered care. The UAB valve team also performs valve-in-valve procedures in the mitral, pulmonic, and tricuspid valve positions. This innovative technology offers options for patients deemed too high risk for an open valve procedure and allows for shorter recovery and a faster return to a better quality of life. Transcatheter valves are implanted using various approaches, such as transfemoral/transcaval, transaortic, transapical, transcarotid, suprasternal, and transaxillary/subclavian. Source: STS Harvest Period #3 - Period ended 6/30/2019 Recent growth in UAB’s Structural Heart and Valve Program will position UAB to be one of the largest TAVR programs in the nation. UAB received an overall composite quality rating of 3 stars in three of the four STS Valve Categories. A 3-star rating denotes that performance is significantly higher than the STS mean, based on 97.5% Bayesian probability. A 2-star rating denotes that UAB’s performance is not statistically different from the STS mean. PROGRAM HIGHLIGHTS OPEN SURGICAL VALVE PROCEDURES BREAKDOWN 2014–2019 (N=4,238) The UAB Structural Heart and Valve Program offers interventional and surgical treatment options including: • Aortic valve replacement/ repair • Tricuspid valve replacement/repair • Pulmonary valve replacement/repair • Mitral valve replacement/ repair • Valve-sparing aortic root replacement • Paravalvular leak repair 8 SURGICAL ISOLATED MV REPAIR VS. TRANSCATHETER MV REPAIR (MITRACLIP) 2014–2019 STRUCTURAL HEART & VALVE DISEASE SURGICAL ISOLATED MVR VS. TRANSCATHETER MVR 2014–2019 UAB Cardiovascular Institute Annual Report Pulmonary Valve Procedures N=80 (1.9%) Aortic Valve Procedures N=3028 (71.4%) Mitral Valve Procedures N=1293 (30.5%) Tricuspid Valve Procedures N=301 (7.1%) • State-of-the-art endovascular/hybrid operating room with a dedicated focus on treating patients with valve disease • Performed more than 1,300 TAVR procedures since program inception in 2012 • Alabama’s most experienced leader in transcatheter valve-in-valve replacement procedures • Identification of potential new transcatheter valves and delivery systems to improve patient safety and effectiveness for those undergoing TAVR • Pediatric cardiologists collaborate closely with structural heart team in treating congenital heart disease. • One of the few medical centers that offers minimally invasive ascending aortic repair/replacement • Performed 250 MitraClip procedures since 2014 • UAB was one of the first on the East Coast to use ABBOTT’s G4 MitraClip device. • UAB was involved in the Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy (COAPT) for Heart Failure Patients with Functional Mitral Regurgitation clinical trial. HIGHLIGHTS • Additional research efforts focus on identifying potential new patient populations that could benefit from the less invasive valve procedures. • UAB’s structural heart and valve team participates in industry-leading clinical trials involving the aortic valve, such as: – EARLY TAVR - Evaluation of Transcatheter Aortic Valve Replacement compared to SurveilLance for patients with Asymptomatic Severe Aortic Stenosis – Reprise IV - Repositionable Percutaneous Replacement of Stenotic Aortic Valve through Implantation of LOTUS Edge Valve System in Intermediate Surgical Risk Subjects uabmedicine.org 9