2020 UAB Cardiovascular Institute Annual Report CVI Annual Report 2019-2020 6 | Page 12

IN-HOSPITAL TAVR MORTALITY TAVR RISK-ADJUSTED MORTALITY ODDS RATIO (R3Y): UAB COMPARED TO TVT REGISTRY UAB’s TAVR program continues to excel with excellent outcomes, as evidenced by these charts from the TVT/NCDR registry 2019 Q1 report. TAVR PROCEDURES: 2012-2019 As UAB’s TAVR volumes continue to increase, the in-house mortality rates have declined. TRANSCATHETER APPROACH TO TAVR 2014-2019 UAB’s valve team has utilized various techniques for implantation of the TAVR valve, tailored to the needs of the patient. Transaxillary/subclavian 3.0% (2.9% 2019 alone) Transcarotid/ suprasternal 2.0% (4.7% 2019 alone) Transaortic 8.0% (5.5% 2019 alone) MITRACLIP MORTALITY OUTCOMES COMPARED TO THE STS/TVT REGISTRY UAB’s structural heart and valve team performed 85 MitraClip procedures in 2019, with mortality rates lower than the STS/TVT registry benchmarks for 30-day and in-hospital mortality. RESEARCH HIGHLIGHTS UAB’s structural heart and valve team participates in industry-leading clinical trials involving the mitral and tricuspid valves, such as: • Summit/MAC – Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation • TRILUMINATE – Clinical Trial to Evaluate Cardiovascular Outcomes in Patients Treated with the Tricuspid Valve Repair System Pivotal TEAM APPROACH AVOIDS NEED FOR EMERGENT TRANSPLANT SURGERY The structural heart team, in close collaboration with UAB pediatric congenital heart surgeons and cardiologists, utilized a successful, alternative-access suprasternal approach, implanting a 34mm Pro Plus TAVR valve in a 14-year-old, avoiding the need for an emergent heart transplant. SELECTED PUBLICATIONS • Ahmed MI, Arisha MJ, Nanda NC, Lewis CTP, Eudailey KW. Usefulness of two- and three-dimensional transesophageal echocardiography in combined mitral valve-in-valve implantation and paraprosthetic leak closure. Echocardiography. 2018 Apr;35(4):501-505. • Chatterjee A, Hillegass WB. “Expanding the frame” for valve-in-valve therapy in small bioprostheses: Encouraging signs for the road ahead. Catheter Cardiovasc Interv. 2018 Sep 1;92(3):555-556. • Chatterjee A, Hillegass WB. Surgical aortic valve replacement and transcatheter aortic valve implantation for severe aortic stenosis: Equipoise remains a tenable assumption. Catheter Cardiovasc Interv. 2018 Aug 1;92(2):431-432. Transfemoral 86.0% (87.0% 2019 alone) 10 UAB Cardiovascular Institute Annual Report uabmedicine.org 11