Discovery of Chemotherapeutic Co-Medication Properties for Multidrug Resistant Cancer
A Minecraft Crowdsourcing Project
effect on the chemotherapeutic response . Identifying the properties of these clusters will help Vogel and Wise to identify new co-medications candidates out of the millions of compounds available . The co-medication data sets are supplied to both Minecraft clients and
This project uses crowdsourcing and game-based volunteer distributed computing via Minecraft to identify properties for co-medications that improve the effectiveness of chemotherapeutics to treat multi-drug resistant cancers . Instrumental researchers include SMU Guildhall Deputy Director of Research , Dr . Corey Clark , and biochemistry professors Pia Vogel and John Wise of the Center for Drug Discovery , Design and Delivery ( CD4 ) at the SMU Dedman College Department of Biological Sciences . servers through the BALANCED Media | Technology HEWMEN Java integration , which allows modders to visualize and manipulate co-medication data directly in Minecraft . Modders , led by FTB and SMU Guildhall , will then build custom Minecraft gameplay systems that will be included into upcoming FTB modpack releases . Each player ’ s interaction with these modpacks simultaneously clusters co-medications , but also supplies a training input into a deep neural network ( DNN ) that is learning and mapping the solution space .
While performing standard gameplay actions in Minecraft , players partition co-medications into two cluster types : ( a ) positive , or improved the effectiveness of chemotherapeutic response , and ( b ) negative , or no
Dr . Clark and his team at SMU Guildhall are developing the distributed DNN for the HEWMEN game-based volunteer grid computing platform , which integrates directly with the Minecraft modpacks .
29